House is evading a former colleague from medical school. He's been sleeping in Wilson's office in order to avoid the old schoolmate.
The patient is a woman who is suffering from excruciating pain. In the show opening a coworker starts feeling intensely ill, just before she suffers intense pain in her head. She is being scanned by Thirteen who says that she has no ability to feel love. She is a psychopath.
The schoolmate of House tracks him down, thanks to an assist by Wilson. House has coffee with Lorenzo Wibberly, awkwardly attempting to make small talk, he asks what Lorenzo has done since medical school. He says that he never graduated. He works in a grocery store. His dad got sick, and he wound up one credit short. House asks which credit. He says he failed on the paper that House had switched on him.
House says, "you're the CEO of this supermarket?" To which Lorenzo says he's a bag boy. "Life works out weird sometimes," he says.
House asks the patient how long she has been a psychopath. She looks surprised. He rattles off a list of things that qualify her as psychopathic, including being a pathological liar. They ask if she poisoned her coworker. She says she just gave hi something to make him feel like vomiting. It wasn't quite a poisoning. House figures out she has a heart arrhythmia.
House finds out the sob story of his former classmate gets worse and worse. His fathers medical bills are piling up, and he was one of "those idiots that got a mortgage with a balloon rate." He's losing his home.
Valerie, the patient, taunts Thirteen, and points out that she can't feel anything (remorse) for doing so. Then Thirteen grabs her arm, and she screams out with agony. Thirteen says she didn't know what happened, but the patient filed a formal complaint against her. Thirteen and Foreman argue about the treatment. House says, "Those of you who haven't slept together can go." Taub stands by and says, "Sorry. That was our secret." Then splits. House tells Foreman and Thirteen to have sex or quit.
Thirteen asks Valerie's husband about where the patient may have become exposed to any sort of toxins. Perhaps in landscaping class. House asks the patient, "when you watch Star Wars, which side do you cheer for?" She points out that Dr. Hadley said she is like House. She says he's as warped as she s and that's why he likes to talk to her.
Her husband finds out that she was not attending a landscaping class. He accuses her of having an affair. She manipulates him saying he can go ahead and check out her story. She makes him feel guilty for accusing her of an affair. He says he's sorry and hugs her, while she glares at Thirteen so as to say, "I played him like a fiddle."
The patent is demanding that Cuddy fire Thirteen. Cuddy says that the patient will not sue, or her husband will find out the truth, and that Dr. Hadley will be removed from contact with her. The patient asks Thirteen if she is going to cry, "because that is one I just can't do."
She gets a phone call and bursts in screaming about the patient accusing her of sexual harassment. Foreman makes her get out of the room. He says that he knows that the charges are bogus, and it will all play out. He then apologizes for firing her. He says he was wrong for doing it.
Foreman explains an emergency surgery to the husband. He says Valerie always made all the decisions. Foreman says it's time to step up and make a decision. The husband asks if she was lying. Did she cheat on him. Foreman says he can't discuss it. The husband says he feels like he doesn't even know her anymore. He sigs and tells Foreman to do whatever needs to be done.
Chase says he gives her a day, maybe two. House says, "Great, you be the clock, everyone else be the doctor."
Wilson asks House what he is doing. He says he's paying Wibberly's mortgage for a few months. Wilson asks why he will help Wibberly but won't apologize to Cuddy. He says that he can't make amends with someone he actually cares about, and that is why he still won't apologize to Cuddy.
Valerie's sister, Sarah, comes to the hospital. Thirteen says she is surprised. She says, "You know what she's like." Sarah says she is not that bad. Her dad was a mean drunk. She wasn't always like this, but she changed in adolescence.
Thirteen tells this to House. He says, "Liver, heart, brain, starts at puberty." House mutters something about raw food diet. Then he says he knows about lipstick lesbians. "Are there nail polish remover bisexuals?" She has an inability to process copper. They are going to treat her with chelation. She asks if that will fix her psychopathy.
Thirteen warns Valerie's husband that she is playing him. She is going to pretend that she is a whole new person once she gets treatment, but she tells him that it won't be real. He says it felt real, and maybe that is enough.
Wibberly asks House if he's really going to pay his mortgage. He says he can't take House's money. He lied. He got an A on the paper and was an orthopedic surgeon for years. He blew it all away on a gambling addiction. House asks why the sob story. Wibberly says he though House would be the same SOB he was in college. House demands he take the check. Then demands again even more forcefully.
Valerie tells her husband he's pathetic. She says it was one thing before he knew, but he knows now and that makes him a chump. He walks away. Thirteen asks why she drove him away. Valerie says it's because he's pathetic. Thirteen says, no. He hasn't changed, but she has. She says Valerie is feeling something or she would just keep sucking him dry. The treatment must be changing her brain. She asks, "what are you feeling?" Valerie says she doesn't know, but it hurts.
Foreman congratulates Thirteen on the diagnosis, while the two make up. Musical outro begins while house looks at Cuddy and Lucas happily together. He takes the mortgage check and slips it in Wibberly's mail slot.